An EDEM simulation analysis of Ctenopharyngodon idella feed pellets based on the Hertz-Mindlin with JKR model was carried out to study the movement and binding conditions of C. idella feed pellets during the conditioning process and optimize feed conditioning conditions. Firstly, a wet sticky model of feed pellets was established using the discrete element theory. Secondly, the impact of conditioning shaft rotational speed and impeller blade installation angle on feed conditioning effect was analyzed by establishing a simulation control group of two factors, conditioning shaft rotational speed and impeller blade installation angle. Then, according to the feed conditioning characteristics requirements, the optimal combination of shaft rotational speed and impeller blade installation angle was determined. Finally, the conclusion was reached through theoretical calculation and simulation analysis: when the conditioning machine's shaft rotational speed was 250 r/min and impeller blade installation angle was 30°, respectively. The feed pellets were not easily attached to the chamber wall, the materials could mix evenly, and the best conditioning effect could be obtained. The results indicated that the conditioning effect of feed conditioner was closely associated with the blade installation angle and the rotational speed of the shaft. This study can offer a theoretical foundation and guidance for feed manufacturers in optimizing and improving conditioning effects.