Pacific oyster (Crassostrea gigas) is a widely aquaculture shellfish in China. Managing the coastal aquaculture area of C. gigas can increase the yield and reduce the losses caused by the environment in Shandong. With the development of remote sensing and artificial intelligence, convenient conditions are provided for evaluating suitability for aquaculture. The autumn-winter fattening aquaculture is an efficient aquaculture method for Pacific oysters. In this study, based on Dynamic Energy Budget (DEB) theory, sea surface temperature, chlorophyll-a and total suspended sediment data obtained by satellites and sea surface height reanalysis data, were used to construct an evaluation model for C. gigas suitability assessment in Shandong Peninsula. The results showed regional differences on the suitability index of fattening aquaculture in Shandong Peninsula, and the overall suitability trend was southern coastal area > northern coastal area > eastern coastal area > western coastal area. The most suitable aquaculture area in the southern coastal area was 9.1%, mainly in Rushan coastal. Several area in the Yellow River mouth area were unsuitable aquaculture area, accounting for as much as 30.5% of the area. The most suitable area of C. gigas fattening aquaculture in Shandong costal area was 38.2% in 2017 and 57.9% in 2019, much more than those of other years. The autumn-winter fattening aquaculture in Shandong for C. gigas was better located in areas with less turbidity, higher chlorophyll-a concentrations, warmer temperatures and fewer waves. The Yellow River estuary was not suitable for the autumn-winter fattening aquaculture due to the high turbidity. The northern and northeastern coastal area of Shandong, such as the northern part of Yantai City and the eastern part of Rongcheng City, were suitable for the fattening aquaculture due to the abundance of Chl.a and clarity of water. In the southern coastal area of the Shandong, such as the southern part of Qingdao City and the southern part of Lushan City, SST was warmer in autumn and winter, allowing oysters to continue to grow and develop, which was ideal for fattening. The results of this study can provide effective quantification and scientific basis for C. gigas aquaculture suitability assessment in Shandong Peninsula.