Developing modern aquaculture seed industry, and leading the green development of aquaculture, will secure the sustainable aquaculture industry in the future. New aquaculture varieties with high quality, high efficiency, multi-resistance and safety advantages should be encouraged to breed and popularize in aquaculture seed industry, and shift from pure high-production yield to high quality, high efficiency, feed saving, drug saving, stress resistant and wide adaptability varieties suitable for ecological and intensive aquaculture mode. In this paper, some problems existing in aquaculture seed industry were analyzed, and indicated that the foundation of high quality, high efficiency and multi-resistance aquaculture varieties is stress resistance. Arrangement of topics related to stress resistance select breeding technology, including stress response, stress recovery, stress coping style and the case studies of stress coping style in animal and poultry seed industry were discussed, the concept of environmental restricted breeding and the future direction of comprehensive stress resistance breeding technology were introduced。This study may lay the foundation to promote sustainable aquaculture in China.