In this paper, red drum (Sciaenops ocellatus) in deep water aquaculture was used as the research object. By studying the main energy material and the change rule of the metabolite during swimming, the physical distribution model in Red Drum was constructed. Then, combined with the specific law of ocean currents to establish the theory of ocean fisheries location. The results showed that in the swimming of red drum, the blood glucose level was significantly increased, the muscle glycogen was reduced slightly, and the liver glycogen was decreased obviously. When the fish swimming closed to fatigue, the liver glycogen level was nearly exhausted. In the process of high speed swimming, the concentration of blood lactic acid and muscle lactic acid was increased obviously, which indicated that red drum swimming process was accompanied by two kinds of energy metabolism processes (anaerobic respiration and aerobic respiration). This study proposed that liver glycogen concentration was used as an important index to determine the swimming ability of fish, and physical distribution model of red drum swimming based on liver glycogen storage energy consumption was established. Finally, based on the physical distribution model of red drum and the law of ocean currents in aquaculture area, the paper put forward the calculation method of selecting maximum flow velocity in red drum aquaculture area. The research showed that the physical distribution model building method of fish swimming and demonstration method of ocean current selection in aquaculture area could provide a new way for the related research, and provide scientific reference for the ocean current selection of marine aquaculture model (deep water cage, shallow sea fence, ect.).