In order to explore the differences between Portunus trituberculatus “Keyong 1”(referred to as “Keyong 1”)and the 1st generation of wild crab(referred to as“common crab”)in terms of growth rate,external characterization and Vibrio alginolyticus resistance,“Keyong 1” and common crab living in the same growth conditions were measured for each morphological trait on the 30th,60th,90th,120th,150th days and according to the injection target body weight,injected into the body cavity with 1.14×10⁷ cfu/mL bacteria of V.alginolyticus at 10 μL/g dose on the 60th,90th,120th,150th days.The results show that “Keyong 1” group was significantly greater than common crab group in body weight on the 60th,90th,120th,150th days;The difference between “Keyong 1” group and common crab group is not significant in external characterization;“Keyong 1” group was significantly stronger than common crab group in resistance to V.alginolyticus on the 60th,90th,120th,150th days.To the same breed P.trituberculatus,the same concentration of V.alginolyticus according to the injection target body weight was injected into the body cavity with 1.14×10⁷ cfu/mL bacteria of V.alginolyticus at 10 μL/g dose had a relatively stable mortality from the 60th to 150th days.