3种免疫途径下迟缓爱德华菌菌蜕疫苗对欧洲鳗的免疫保护效果

doi:10.3724/SP.J.1231.2014.49341

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3种免疫途径下迟缓爱德华菌菌蜕疫苗对欧洲鳗的免疫保护效果
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                        10.3724/SP.J.1231.2014.49341
                    
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作者单位:中国水产科学研究院珠江水产研究所,中国水产科学研究院珠江水产研究所,中国水产科学研究院珠江水产研究所,中国水产科学研究院珠江水产研究所,中国水产科学研究院珠江水产研究所,中国水产科学研究院珠江水产研究所,中国水产科学研究院珠江水产研究所,中国水产科学研究院珠江水产研究所
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基金项目:国家自然科学基金(31202032);广州市珠江科技新星专项(2012J2200078);广东省海洋渔业科技推广专项(A201301B06)

Immune efficacy of Edwardsiella tarda ghosts vaccine for European eel (Anguilla anguilla)by 3 kinds of inoculation routes

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Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Fishery Drug Development,Ministry of Agriculture,Key Laboratory of Aquatic Animal Immune Technology,Guangdong Province;PR China,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Fishery Drug Development,Ministry of Agriculture,Key Laboratory of Aquatic Animal Immune Technology,Guangdong Province;PR China,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Fishery Drug Development,Ministry of Agriculture,Key Laboratory of Aquatic Animal Immune Technology,Guangdong Province;PR China,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Fishery Drug Development,Ministry of Agriculture,Key Laboratory of Aquatic Animal Immune Technology,Guangdong Province;PR China,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Fishery Drug Development,Ministry of Agriculture,Key Laboratory of Aquatic Animal Immune Technology,Guangdong Province;PR China,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Fishery Drug Development,Ministry of Agriculture,Key Laboratory of Aquatic Animal Immune Technology,Guangdong Province;PR China,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Fishery Drug Development,Ministry of Agriculture,Key Laboratory of Aquatic Animal Immune Technology,Guangdong Province;PR China,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Fishery Drug Development,Ministry of Agriculture,Key Laboratory of Aquatic Animal Immune Technology,Guangdong Province;PR China

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摘要:

为了探讨迟缓爱德华菌菌蜕疫苗预防鳗鲡爱德华菌病的可行性,实验采用腹腔注射、口服、浸泡3种途径探讨了迟缓爱德华菌菌蜕疫苗对欧洲鳗的免疫保护效果.结果表明,免疫后欧洲鳗血清抗体效价均明显升高,但菌蜕疫苗(ETG)组与福尔马林灭活疫苗(FKC)组间血清抗体效价无显著性差异.欧洲鳗注射、口服、浸泡ETG组的相对免疫保护率分别为75.0%、52.5%、37.5%,分别高于FKC组的55.0%、40.0%、32.5%,且ETG组欧洲鳗死亡时间明显推后,表明菌蜕疫苗的免疫保护效果优于福尔马林灭活疫苗.易操作、对鱼体应激少的ETG疫苗口服免疫欧洲鳗获得了52.5%的免疫保护率,在预防鳗鲡爱德华菌病中具有良好的应用前景.

Abstract:

Edwardsiellosis caused by Edwardsiella tarda is one of the most serious diseases in the eel culture industry.Bacterial ghosts,which have native surface antigenic structures and can induce humoral and cellular immune response,have become an important candidate of vaccine development.In present study,immune efficacy of E.tarda ghosts vaccine for European eel was detected in 3 kinds of inoculation routes.Results indicate that antibody titer of European eel shows significant increase after immunization with E.tarda ghost(ETG)and Formalin killed cell(FKC),but there is no significant difference between ETG group and FKC group.The relative protective survival(RPS)of ETG by intraperitoneal injection and immersion and oral administration are 75.0%,52.5%,37.5% respectively,is higher than FKC's 55.0%,40.0%,32.5% respectively.Moreover,the beginning of death time of eel immunization with ETG has a delay compared with FKC.Above results indicate that immune efficacy of ETG was superior to FKC.In particular RPS of ETG is 52.5% by oral administration.Considering easily operating and less stress,oral immunization of ETG has a favorable application prospect in preventing Edwardsiellosis of eel industry.

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李宁求,余露军,付小哲,刘礼辉,林强,张德锋,石存斌,吴淑勤.3种免疫途径下迟缓爱德华菌菌蜕疫苗对欧洲鳗的免疫保护效果[J].水产学报,2014,38(11):1910~1916

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收稿日期:2014-06-13
最后修改日期:2014-09-17
录用日期:2014-10-14
在线发布日期: 2014-11-18
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