Under the conditions of synthetic water,the exposure method of mixed system and sequential system were adopted,the interaction of the two metals(Zn and Cd)was studied in different organs and tissues(gill,hepatopancreas,muscle)of the Eriocheir sinensis,in the process of absorbing accumulating heavy metal.The results show that the interaction of Zn and Cd was influenced by the exposure concentration,tissues and organs,the exposure time.In the mixed exposure system,Zn and Cd in the hepatopancreas showed a clear synergistic effect.In the gills,low concentration exposure showed synergistic,high concentration exposure showed antagonism.In the muscle,no significant change in the law.In the sequential exposure system,compared with the mixedexposure system,different organs and tissue content of Zn and Cd reduced significantly(P<0.05).The addition of Cd,will reduce the Zn concentration in the gill and hepatopancreas of Eriocheir sinensis in the Zn pre-exposure system,Zn content and Cd concentration have the antiexposurerelated,and Zn in the muscle did not change significantly.The addition of Zn,will increase the concentration of Cd in the Cd pre-exposure system of Eriocheir sinensis in gills,hepatopancreas and muscle,and hepatopancreas and muscle of Cd and Zn content were positively related to exposure concentration.