Statoliths are paired calcified structures within the statocyst providing a sense of balance, and they are also an acceleration receptor showing much information about biology and ecology over the life span. With the study and application gradually elevation and improvement for otolith microchemistry of fish, corresponding study in the statolith of cephalopod become popular. Recently, microchemistry study is one of hot topics in fishery animal, and more and more scientists are interested in it as so much biology and ecology information was showed. For the purpose of providing some reference to the researchers, studies of microchemical structure of cephalopod statoliths were reviewed. Presently, the main contents for microchemistry study in cephalopod statolith are composed of inorganic and organic molecules, minor and trace elements, isotope as well as microchemical markers. Minor and trace elements were the important part among the application, which played an important role in discriminating different populations, analyzing life history and reconstructing inhabited environment condition. Some good results have been shown regarding relationship between the elements and environment condition especially water temperature, some of which were considered as a thermometer for reconstructing environment temperature. However, studies refer to population discriminating, life history analyzing and influence by salinity and food for the elements were not enough, moreover, most of study concentrated on strontium to calcium. Therefore, we proposed that the elements value study should be performed at daily level according to different temporal and spatial serial in the further research.