The techniques on the regulation-controlling the recirculation water of indoor industrial culturing of Penaeus vannamei were studied making use of the system of circulating water treatment. This system mainly consisted of ozonator, air-liquid mixer, air compressor, foam separator and rough filter etc. The initial water before culturing and the recirculating water from shrimp culture pond before every recirculation treating during the culture experiment were treated for 4 h, then aired for 2 h in the sterilizing pond with only ozone. About 99.3% bacterial total was sterilizing and vibrio total was smaller than 1 cell·mL^-1 by such treating initial water. The culture pond water during the culture was recircularly treated for about 12 h at 4-6 d intervals with the system of the circulating water treatment in order to remove NH₃-N_t, NO^-₂-N, organism, suspended matter and bacterial etc. The frequency of using foam separating and rough filter to treating recirculation water was increased and pH was regulated with caustic lime water according to the quality of recirculating water after culturing for about 60 d. The quality of recirculating water was effectively controlled by the system of recirculating water treatment. The quality criteria of the recirculation water for use as the shrimp culture was controlled within suitable range without using any medicine and water exchanging during culture period for128 d. The average values of main parameter were as follows: turbidity 13.9 NTU，pH 8.08, oxidation-reduction 399 mV，NH₃-N^t（NH₃-N_m）0.267 mg·L^-1 (0.013 mg·L^-1)，NO^-₂-N 0.203 mg·L^-1，COD_Mn 10.34 mg·L^-1. The average body weight of harvest shrimp 13.56 g，survival rate 59.6%，yield in per cubic meter water 4.27 kg·m^-3, bait coefficient 1.01. The mode on regulating-controlling recirculation water for indoor industrial culture of prawn is proposed according to the experiment result and culturing character of Penaeus vannamei.