本试验用鼠伤寒沙门氏菌组氨酸缺陷型——哺乳动物肝微粒体酶测试系统(Amer'Test),对正烷酵母饵料浸出液的非极性树脂 XAD-2 吸附物进行检测,以查明其是否具有致突变或致癌作用。结果表明,正烷酵母对菌株 TA98及 TA100有致突变作用,由此证明这种饵料中存在着引起 DNA 移码突变和碱基对置换突变的化合物,故这种酵母在被用作鱼类饵料或其他动物饲料之前,还应作进一步研究,防止其对环境的污染和其他潜在的危害性。
Abstract:
Materials in the experiments were prepared by absorbing tb.e extracts of fish food N-Paraffin yeast. They were tested,ar znu enic properties by using the Sal.monallaTyphimurium microsomal test system. Mutagenic activity was detected in the prepared N-Paraffin yeast materials. It re-eals that this fish food may contain the compound of flameshift and base.-pair substitution mutagens. It required metabolic activations. Therefore great care should he taken in using this yeast as the food of fish or other animals in order to av aid the potential harmfulness.