According to different mixture ratios of four initial feedings [Artemia(Art), Tubifex(Tub), Microparticulate diet (MD) and Spirulina (Spi)], we divided the 10-day-post-hatching (10 dph) larvae into 8 groups at water temperature (24 ± 0.5) ℃ to investigate the effects of early weaning and co-feeding on the growth and digestive capacity of Myxocyprinus asiaticus larvae. There were two groups(Art, Tub) which kept on feeding previous diet and the rest all turned to the microparticulate diet after 40 dph. We recorded the survival rate of each group and measured length, weight and some enzyme activity at different intervals (30, 40, 45, 55 and 65 dph). Results showed that: ① the survival rate of each group performed equally and was greater than 90% before weaning at 40 dph, but the weaned groups gradually decreased after that period. The survival rates of groups (Art, Tub) fed the same diets were significantly higher than those of the corresponding weaning groups (Art/MD, Tub/MD) and the other weaning groups (P<0.05) at the end of experiment. ② Weaning had little effects on the amylase activity of M. asiaticus larvae and the trypsin activity of Art group, but significantly influenced the trypsin activity of Tub group (P<0.05). After 40 dph,there were differences in lipase activity of the Art and Tub groups,but those weaning groups (Art/MD, Tub/MD) had similar trend; ③ The weight and length of these two co-feeding groups (Art + MD + Spi/MD Tub + MD + Spi/MD) were all less than those groups (Art + Spi, Tub + Spi) correspondingly before weaning; ④ The amylase activity of the co-feeding groups and the corresponding groups were all on the rise after weaning, and the co-feeding groups were a little higher than the corresponding groups (P > 0.05). The trends of those two co-feeding groups' trypsin and alkaline phosphatase activity fluctuation were not significant before weaning, but the lipase activity of the co-feeding groups had a special change of descending first, and then ascending on the 5th day after weaning. To sum up, it was a feasible strategy to co-feed M. asiaticus larvae with 3 diets (Art, Spi and MD) and wean on 40 dph, but the ratio and addition time of MD need further study.