The effect of replacing fish meal with raw and various processed soybeans meal on growth and protein metabolism of common carp Cyprinus carpio was evaluated in an 8week trial. The common carp fingerlings［initial body weight(5.89±0.36) g］ were fed five isonitrogenous and isocaloric feeds(30% digestible protein and 15 MJ/kg digestible energy) containing SBM replacing 50% of the fish meal protein,such as raw soybean(RSB), processed soybean by chemical inactivator, processed soybean by heating, processed soybean by heat alcohol, respectively. Results showed that weight gain of control were significantly different（P>0.05），but those fed RSB were significantly lower than control（P<0.05）,those fed processed soybeans by chemical inactivator and by heating and by heat alcohol had no significant difference, but all significantly higher than control. Protease specific activity of control in the intestine and hepatopancreas was significantly higher than those fed RSB and processed soybeans by heat alcohol,but both had no significant difference with those fed processed soybeans by chemical inactivator and by heating（P>0.05）. RNA of 100% fish meal and 50% processed soybean by heating in white muscle were no significant difference(P>0.05），but both were significantly higher than those fed RSB and processed soybeans by heat alcohol and by chemical inactivator and by heating, RNA/DNA of 100% fish meal and 50% processed soybean by heating and by chemical inactivator in white muscle had no significant difference(P>0.05），but all were higher than those fed raw soybean(RSB) and processed soybean by heat alcohol（P<0.05）. RNA in white muscle and serum IGF-I had a positive correlation with growth(P<0.05).The degree of negative effect of soybean antinutritional factors on fish is antitrypsin inhibitor>agglutinin>soybean antigen protein under the experimental conditions, and proper control could reduce the negative impact of soybean antinutritional factors on fish.