Studies on hybridization between Mytilus galloprovincialis and Mytilus coruscus and pilot-scale breeding were carried out from 2005 to 2007. F₁ were obtained with technologies of intensive culture of parental mussel, identification of male and female, amelioration of waterbodies exchange of breeding, feeding compound tiny algae, et at. The results show that the growth characters are positive cross F₁> _{M. galloprovincialis}> _M.coruscus> negative cross F₁. 377 million juvenile mussels of positive cross F₁ with shell length of 1.13 mm, shell height of 0.78 mm were obtained. The survival ratio reaches 37%. Advantages of positive cross F₁ exist in shell length, shell height, survival ratio, when compared with M.galloprovincialis and M. coruscus. But the hatching rate is lower. No obvious advantages were found in negative cross F₁.