Pond ecosystem is a complicated system with the characteristic of dynamic state, multiple factor and unrepresentative. It was difficult to give out results for cultivation problem via single factor statistic traditionally. The paper studied the model optimization of relationship between Siniperca chuatsi health index and seventeen aquatic ecological factors of Siniperca chuatsi culturing pond. The ecological factors involved pH value, ammonia nitrogen content, nitrate content, CO₂ content, Mg^2＋ content, total alkalinity and general bacterial population, et al. Sampled water with plexiglass water sampler every two weeks between 8:00 a.m. to 9:00 a.m. Siniperca chuatsi health examination was done at the same time as water sampling. Employing the statistics as weight factor、F inspection value、Partial regression square-sum and correlation coefficient et al., the superiority model factors were obtained by mathematical statistics to 87 group of experiment data. A non-linear model between the superiority seven factors(pH、NH^4＋-N、NO^3--N 、CO₂ 、total alkalinity、Mg₂₊、bacteria counts) and the siniperca chuatsi health comprehensive indicators were regressed and expressed as y＝a0＋ ＋ ＋ . Its precision was 92.1%. By means of the model, optimization cultivation conditions were analyzed, in order to do favor to ecological culture. The most effect factors on y which coming from the model were bacteria counts、CO2、pH and NH^4＋-N, and their best range took turns 13~27×104 cfu*L^-1、less than 3 mL*L^-1、7.5~8.0 and 0.5 mL*L^-1。