Heavy metal pollution in benthic filter-feeding bivalves has been received more and more attention. With regard to the studies in this field, the two-compartment kinetic model is a new developed mathematic model. In the present study, accumulation and elimination of three heavy metals (Cu, Pb, and Cd) in Tegillarca granosa Linnaeus were investigated in a semi-static system. Kinetic parameters of bioconcentration were obtained form the two-compartment model by nonlinear curve fitting, including uptake rate constant (K¹), elimination rate constant (K²), bioconcentration factor (BCF), and biological half-life (B1/2). It was found that the metal concentration data were fitted to the two-compartment model, and good agreement was found between the predicted and observed metal concentration using the goodness-of-fit test. The modeling results showed that K1 ranged from 7.318 to 29.928, K2 ranged from 0.0064 to 0.0176, BCF ranged from 457.3 to 3303.6, and B1/2 ranged from 39.4 to 108.3. The results also indicated that the uptake rate constant (K¹) and bioconcentration factor (BCF ) generally decreased with the increase of heavy metal exposure concentration in ambient seawater, the bioaccumulation ability order of T. granosa to the three heavy metals was Pb,Cd,Cu, the biological half-life of Pb in T. granosa was longer than those of Cd and Cu, maximal content in the organism (CAmax) at the theoretic equilibrium increased and was basically directly proportiona1 with increasing metal concentration in the outside water. So it could be regarded that the heavy metal concentration in T. granosa faithfully reflected the contaminations status and process of the ambient surroundings, accordingly T. granosa could be regarded as the indicator of the three heavy metals in coastal waters of Zhejiang province and other waters with the distribution of T. granosa.